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To observe the effects of venoms from Korean Agkistrodon snakes; Agkistrodon b. brevicaudus, Agkistrodon caliginosus and Agkistrodon saxatilis, basic hematologic examination were done in mice after venom injection by 0.37㎎, 0.21㎎ and 0.03㎎ by subcutaneusly. Venom were injected subcutaneusly by 0.37㎎, 0.21㎎ and 0.30㎎, respectively, in each mice. Mice were sacrificed on 5min, 15min, 30min, 1hr., 3hr., 6hr, 5day and 7day. Each group consisted of 5mice. Basic hematologic examinations include WBC, RBC, Hb, MCV, RDW(red blood cell distribution width) and platelets. Results obtained were as follows; 1. The effects of Agkistrodon b. brevicaudus venom Changes of WBC were not significant. RBC were increased at early stage but progressively decreased to 5.3±1.8(×10^12/l). Hb showed similar pattern with RBC. MCV was slightly decreased to 50.7fl. RDW were within normal limits. Platelets were markedly and progressively decreased to 114.4±40.9(×10^9/l). 2. The effects of Agkistrodon caliginosus venom Changes of WBC were not significant. RBC were pregressively decreased to 5.8±0.2(×10^12/l). Hb showed similar pattern with RBC. MCV were decreased in early stage but increased to 56.3±2.8fl on 7th day. RDW were within normal limits. Platelets were progressively decreased to 494.3±114.5(×10^9/l). 3. The effects of Agkistrodon saxatilis venom Changes of WBC were not significant. RBC were progressively decreased to 4.4±0.4(×10^12/l). Hb showed similar pattern with RBC. MCV were increased later. RDW were within normal limits. Platelets were markedly and progressively decreased to 40.2±13.8(×10^12/l) 4. Therefore, venoms from Korean Agkistrodon snakes showed similar basic hematologic effects in the blood of mice by marked decrease of RBC and platelets. The hematoxic effects were most severe in A. saxatilis, A. b. brevicaudus and mild in A. caliginosus.
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